Protein Details: Protein orai
Protein ID
ICDB_Pro_1037
Protein Name
Protein orai
Gene Name
orai-1; CBG15255
Organism
Caenorhabditis briggsae
Length
300 amino acids
AlphaFoldDB
AF-Q616J1-F1-model_v4.pdb
Function
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor; stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function (By similarity).
Sequence
MPRSHDPSRVELLRQEGSTMNEKRVSISVEDIRGAVATWKTTSGAPITPYPLPQFFLQPPSSGGGSRNVGGGDGAAGNSKNGSMNSLRMQAYAKKTDDDVDLGHRGELDLSEKYNYDLSKAQLKASSRTSALLAGFAMVCLVELQYDDSTSKPLLIVLGVVTSLLVSVHLLALMMSTCILPYMEATGCTQDSPHLKLKFYIDLSWLFSTCIGLLLFLVEIGVIFYVKFTAVGYPTAGYITTAMLIPVGIVFVLFSYLIHKNRVSHSLGRFKDKVDTMKQFLDVEANLQKSTIAPSTIRDI
PDB Structures
Ligand Binding
Binding Site
Disease
Location
DOI ID
10.1371/journal.pbio.0000045
RefSeq
XP_002642971.1